Chondroitin sulfate (CS) is a class of glycosaminoglycans covalently linked to proteins to form proteoglycans. Chondroitin sulfate is widely distributed in the extracellular matrix and cell surface of animal tissues. The sugar chain is composed of alternating glucuronic acid and N-acetylgalactosamine (also known as N-acetylgalactosamine) disaccharide units through a sugar-like substance. The linker region is attached to the serine residue of the core protein. At present, the main sources of chondroitin sulfate extraction are sharks, cattle, pigs, and chicken cartilage.
In Europe, America, Japan and other countries, chondroitin sulfate is mainly used as a health food or medicine for the prevention and treatment of diseases such as arthritis, coronary heart disease, keratitis and angina pectoris.
1, chondroitin sulfate has a strong role in scavenging oxygen free radicals
There are many types of oxygen free radicals that cause oxidative damage in the human body, and the hydroxyl radical superoxide anion radicals have the strongest activity. Studies have shown that chondroitin sulfate hydroxyl radical scavenging activity and superoxide anion free radical activity are relatively high, the half inhibitory concentrations are 8.77mg / mL and 0.94mg / mL, respectively, the scavenging capacity and chondroitin sulfate concentration and purity process positive Related. Chondroitin sulfate has a strong antioxidant capacity, thereby protecting the body from oxidative damage of oxygen free radicals and exerting anti-aging effects.
2, the prevention and treatment of chondroitin sulfate on arthritis
The main application of chondroitin sulfate in medicine is as a medicine for treating joint diseases. It is used together with glucosamine to relieve joint pain and promote cartilage regeneration, and can fundamentally improve joint problems. In the United States, chondroitin sulfate is used as a dietary supplement to bind water molecules for lubrication and support joints. Chondroitin sulfate can be improved to make joint movements free.
3, chondroitin sulfate has the role of prevention and treatment of osteoporosis
Studies have shown that chondroitin sulfate can significantly increase bone mineral content and bone density, reduce serum alkaline phosphatase levels, can significantly improve the biomechanical parameters of the femur, and thus have a therapeutic effect on osteoporosis.
4, the protective effect of chondroitin sulfate in the eye
Chondroitin has a protective effect on corneal collagen fibers, which can promote the healing of corneal wounds, the absorption of exudate and the elimination of inflammation. Chondroitin sulfate is combined with other drugs to form a compound eye drop for preventing visual fatigue, conjunctival hyperemia, itchy eyes, and treating dry eye syndrome.
5, other functions
Chondroitin sulfate can also treat neurological headache, trigeminal neuralgia, coronary heart disease, angina pectoris, myocardial hypoxia, cardiovascular and cerebrovascular diseases, joint pain, atherosclerosis and hepatitis. In addition, chondroitin sulfate also has anticoagulant and antithrombotic effects, and can also be used for adjuvant treatment of hearing impairment and liver function damage caused by streptomycin and adjuvant treatment of hyperlipemia.
Chondroitin sulfate has been widely used in the fields of medicine and nutrition and health for its unique biological activity. At present, China is a major producer and exporter of chondroitin sulfate, and 80% of the world's chondroitin sulfate is produced in China. With the deepening of research, the detection methods for the quality, adulteration and purity of chondroitin sulfate are more and more abundant, and the quality requirements of domestic and foreign customers are getting higher and higher